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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CHEK2
All Species:
24.85
Human Site:
T168
Identified Species:
39.05
UniProt:
O96017
Number Species:
14
Phosphosite Substitution
Charge Score:
0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O96017
NP_001005735.1
543
60915
T168
E
D
H
S
G
N
G
T
F
V
N
T
E
L
V
Chimpanzee
Pan troglodytes
XP_001172779
543
60866
T168
E
D
H
S
G
N
G
T
F
V
N
T
E
L
V
Rhesus Macaque
Macaca mulatta
XP_001102484
543
60923
T168
E
D
H
S
G
N
G
T
F
V
N
T
E
L
V
Dog
Lupus familis
XP_543464
544
61233
T169
E
D
H
S
G
N
G
T
F
V
N
R
E
L
V
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z265
546
61070
T172
E
D
H
S
G
N
G
T
F
V
N
T
E
L
I
Rat
Rattus norvegicus
NP_446129
545
60912
T171
E
D
H
S
G
N
G
T
F
V
N
T
E
L
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508699
537
60493
L161
G
K
G
K
R
L
V
L
S
N
N
S
E
I
A
Chicken
Gallus gallus
NP_001073576
522
58779
E165
L
P
L
T
H
N
S
E
I
A
L
S
I
Q
T
Frog
Xenopus laevis
NP_001082016
517
58243
A159
T
L
P
L
T
N
N
A
E
I
A
L
S
L
P
Zebra Danio
Brachydanio rerio
Q501V0
422
47914
A86
K
K
V
A
K
Y
R
A
K
F
D
P
R
V
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O61267
476
54243
D141
M
R
I
L
K
N
D
D
V
I
S
L
S
H
P
Honey Bee
Apis mellifera
XP_624334
480
54300
V144
Q
P
I
V
I
V
Y
V
F
M
S
T
T
A
F
Nematode Worm
Caenorhab. elegans
Q9U1Y5
476
53320
I141
E
L
M
N
G
D
L
I
S
I
G
I
P
A
L
Sea Urchin
Strong. purpuratus
XP_794585
480
52849
G144
S
N
G
T
F
V
N
G
E
K
I
A
Y
V
F
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P39009
513
58614
S158
K
V
S
S
E
S
R
S
Y
K
N
D
D
E
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
99
89.3
N.A.
83.1
83.4
N.A.
74.4
67.5
59.6
28.1
N.A.
34
37.2
30.2
43.2
Protein Similarity:
100
99.8
99
93
N.A.
89.7
89.9
N.A.
82.1
77.9
73.1
41.9
N.A.
51.5
54.5
49.5
58.3
P-Site Identity:
100
100
100
93.3
N.A.
93.3
93.3
N.A.
13.3
6.6
13.3
0
N.A.
6.6
13.3
13.3
0
P-Site Similarity:
100
100
100
93.3
N.A.
100
100
N.A.
26.6
20
20
26.6
N.A.
20
33.3
40
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
28.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
47.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
53.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
7
0
0
0
14
0
7
7
7
0
14
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
40
0
0
0
7
7
7
0
0
7
7
7
0
0
% D
% Glu:
47
0
0
0
7
0
0
7
14
0
0
0
47
7
0
% E
% Phe:
0
0
0
0
7
0
0
0
47
7
0
0
0
0
14
% F
% Gly:
7
0
14
0
47
0
40
7
0
0
7
0
0
0
0
% G
% His:
0
0
40
0
7
0
0
0
0
0
0
0
0
7
0
% H
% Ile:
0
0
14
0
7
0
0
7
7
20
7
7
7
7
14
% I
% Lys:
14
14
0
7
14
0
0
0
7
14
0
0
0
0
0
% K
% Leu:
7
14
7
14
0
7
7
7
0
0
7
14
0
47
7
% L
% Met:
7
0
7
0
0
0
0
0
0
7
0
0
0
0
0
% M
% Asn:
0
7
0
7
0
60
14
0
0
7
54
0
0
0
0
% N
% Pro:
0
14
7
0
0
0
0
0
0
0
0
7
7
0
14
% P
% Gln:
7
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% Q
% Arg:
0
7
0
0
7
0
14
0
0
0
0
7
7
0
0
% R
% Ser:
7
0
7
47
0
7
7
7
14
0
14
14
14
0
0
% S
% Thr:
7
0
0
14
7
0
0
40
0
0
0
40
7
0
14
% T
% Val:
0
7
7
7
0
14
7
7
7
40
0
0
0
14
34
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
7
7
0
7
0
0
0
7
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _